Its pathogenesis is still unclear. Many mechanisms, such as autoimmune, autocytotoxic, biochemical, and neural mechanisms, have been suggested.
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The cytotoxic T cells responsible for the destruction of melanocytes and the disappearance of melanin are eliminated by phototherapy through apoptosis, contributing to diffuse repigmentation.
UVB does stimulate melanocyte proliferation and migration to the epidermis from nearby follicular units, leading to follicular repigmentation.
It also stimulates perilesional active melanocytes, leading to marginal repigmentation.
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